MOTS-C 20mg (Mitochondrial Open-Reading-Frame of the Twelve S rRNA-c) is a peptide naturally encoded within mitochondrial DNA. It plays a key role in regulating glucose metabolism, fatty acid oxidation, and cellular stress resistance. When supplemented, MOTS-C 20mg enhances mitochondrial efficiency, improves insulin sensitivity, and supports energy utilisation at a cellular level.
In performance and wellness settings, MOTS-C 20mg is valued for its ability to improve endurance, assist fat loss, and support metabolic resilience, particularly during calorie restriction or intense training. Unlike stimulants or anabolic agents, its effects are systemic and metabolic rather than hormonal, making it suitable for both performance optimisation and longevity-focused protocols.
Benefits• Enhances mitochondrial function and energy production• Improves insulin sensitivity and glucose utilisation• Supports fat oxidation and metabolic efficiency• May increase endurance and exercise capacity• Supports cellular stress resistance• Non-hormonal mechanism of action• Suitable for metabolic and longevity protocols
Side Effects• Mild headache• Temporary fatigue• Injection site irritation• Nausea (rare)• Dizziness (rare)
Dosages & ProtocolBeginner: 5mg, 2× per weekIntermediate: 10mg per week, split into 2 dosesAdvanced: 15–20mg per week, split into 2–3 doses
MOT-C 20mg is typically used in cycles of 2–4 weeks, followed by a short break before repeating.
How to Administer• Remove the protective cap from the MOTS-C 20mg vial.• Clean the rubber stopper with an alcohol swab.• Using a sterile syringe, draw bacteriostatic water (commonly 2ml).• Slowly inject the water down the side of the vial.• Gently swirl until fully dissolved (do not shake).• Draw the required dose using an insulin syringe.• Administer via subcutaneous injection into the abdomen, thigh, or upper arm.• Rotate injection sites regularly.
Storage• Store lyophilised vial refrigerated prior to reconstitution.• After reconstitution, store at 2–8°C.• Use within 30 days after reconstitution• Do not freeze.• Protect from light.
Half-Life & DetectabilityMOTS-C: Short circulating half-life with sustained metabolic activity.Detectability: Not commonly included in standard drug testing panels.For athletes subject to drug testing, it is important to consider these detection times and plan accordingly to avoid positive tests for banned substances.
