Description

DSIP

Synonyms / Designations: DSIP, Delta Sleep–Inducing Peptide, Delta sleep peptideCAS Number: 62568-57-4Molecular Formula: C₃₅H₄₈N₁₀O₁₅Molecular Weight:~848.82 g/molPeptide Classification: Naturally occurring nonapeptide; classified as a neuropeptide in experimental modelsPurity: ≥ 99 % (HPLC, typical)Appearance: White to off-white lyophilised powderPack Size: 2.5 mg (total)Storage: Desiccated, protected from light, stored at –20 °CSolubility: Soluble in water, dilute acetic acid, and phosphate-buffered saline (PBS)

Description & Mechanism

Delta Sleep–Inducing Peptide (DSIP) is a naturally occurring nonapeptide first identified in studies of neurochemical signaling associated with sleep-related brain activity. It has been detected in central nervous system tissues, peripheral organs, and various biological fluids across multiple animal models, although its biosynthetic origin and precursor structure remain incompletely characterized.

In biochemical and cellular research systems, DSIP has been examined for its involvement in neuroendocrine signaling, stress-associated pathways, and peptide–receptor interactions. Experimental studies suggest that DSIP may interact with multiple signaling mechanisms, including NMDA receptor–related pathways and MAPK-associated signaling cascades, with observed effects dependent on concentration, exposure duration, and experimental context. DSIP is primarily utilized as a molecular tool to investigate neuropeptide signaling rather than defined physiological outcomes.

Applications in Research

• As a molecular probe for studying neuropeptide-mediated signaling in central nervous system models

• Investigation of peptide interactions within neuroendocrine and stress-related pathways

• In vitro studies examining peptide stability, degradation, and carrier-protein interactions

• As a reference compound in research involving short endogenous neuropeptides

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic

• Reconstitute in sterile water, dilute acetic acid, or appropriate buffered aqueous solution depending on assay requirements

• Avoid vigorous agitation during dissolution

• Filter sterilize if required (e.g. 0.22 µm) immediately prior to use

• Aliquot and store reconstituted solutions at –20 °C (or lower) to minimize degradation

• Avoid repeated freeze–thaw cycles

• Due to reported low intrinsic stability in vitro, prepare fresh working solutions when possible